Sarkomy Kostej Magkih Tkanej i Opuholi Kozi
Analysis of anaplastic lymphoma kinase status in rhabdomyosarcomas: correlation with clinicopathological findings
Rhabdomyosarcoma (RMS) is a highly malignant tumor occurring mostly in children. Multimodal therapy is currently promising, however, in patients with high risk (per the stratification scale) low survival rates are observed. There remains a necessity for new possibilities in treatment of this category of patients. Currently, anaplastic lympho- ma kinase (ALK) is of considerable interest. To study expression of ALK as a potential target marker in RMS tissues. In total, 202 histological RMS blocks were studied. ALK expression was qualitatively measured using immunohistochemistry, and its corre
Read MoreClinical and molecular features of neurofibromatosis types 1 and 2: a review of the literature
Neurofibromatosis is a neurocutaneous syndrome characterized by the development of tumors of the central or peripheral nervous system including the brain, spinal cord, organs, skin, and bones. There are three types of neurofibromatosis: type 1 (96 of cases), type 2 (3 % of cases), and schwannomatosis (less than 1 % of cases). The NF1 gene is located on chromosome 17q11.2, which encodes for a tumor suppressor protein, neurofibromin, that functions as a negative regulator of Ras / MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinases) / mTOR (mamma- lian target of rapam
Read MoreFunctional results in the surgical treatment of a tumor lesion of the proximal humerus with endoprosthetics
The article presents current trends in surgical treatment for oncological endoprosthesis of the shoulder joint. The main benefits and disadvantages of the 2 main techniques used in shoulder joint endoprosthesis are analyzed. Possibilities of their use in certain groups of patients are considered. To systemize and analyze the results of using anatomical and reverse endoprosthesis, consider possibilities of optimization of selection of treatment tactics.
Read MoreCardiooncology: current status of the issue, interdisciplinary interaction
Current methos of treatment of oncological pathology significantly increase survival rates and patients’ lifespan. However, treatment of malignant tumors leads to development of adverse reactions decreasing its effectiveness and negatively affecting quality of life and survival. It was shown that short- and long-term cardiovascular complications significantly affect the results of therapy. The article presents data on current scientific research in cardio-oncology touching on the problems of cardiotoxicity, concomitant cardiological disorders in oncological patients, cardiac rehabilit
Read MoreDiagnostic And Treatment Of Secondary Chondrosarcoma Of The Femur With Multiple Recurrences: Case Report
Chondrosarcomas are one of the most common bone tumors in adults. Resectable chondrosarcomas require surgical removal and are prone to local recurrence, often multiple. The article presents a clinical observation of secondary chondrosarcoma of the femur that arose against the background of osteochondroma in a 38-year-old patient. The example shows the role of a multidisciplinary team in choosing the tactics of primary treatment of the patient, as well as in the process of multiple recurrence of the tumor.
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