Sarkomy Kostej Magkih Tkanej i Opuholi Kozi
TRABECTEDIN IN THE TREATMENT OF SOFT TISSUE SARCOMAS: UP TO DATE DATA
Soft tissue sarcomas are a rare heterogeneous group of malignant tumors with mesenchymal nature. Soft tissue sarcomas accounts for less than 1 % of all cancers. Low efficiency of chemotherapy for soft tissue sarcomas, especially in advanced disease, is a burning issue. Trabectedin is one of the active agents approved for the treatment of advanced soft tissue sarcomas after the failure of standard chemotherapy. The article provides a literature review of the latest world-wide data of the effectiveness and role of trabectedin in the modern approach of soft tissue sarcomas treatment.
Read MoreComparative analysis of the CYP2D6 metabolic activity and its effect on its effect on the treatment results of primary breast cancer
Standard treatment for hormone receptor-positive breast cancer includes long-term hormone therapy. However, treatment efficacy varies even in homogeneous groups of patients. Tamoxifen is metabolized in the liver, resulting in the production of endoxifen, its active metabolite. Cytochromes P450 (CYP2D6, etc.) play a major role in converting tamoxifen to endoxifen. The CYP2D6 gene is extremely polymorphic and has more than 100 alleles that can encode normal, high, and low metabolic activity or be inactive. Thus, patients can be divided into three groups according to the presence or absence of
Read MorePublic Experimental public study on seismic performance of multi-story prefabricated shear wall
A novel multi-story prefabricated shear wall structure was investigated, in which reinforcement anchor rings or steel wire rope sleeve was used for the vertical joint connection, while the vertical rebar was connected by noncontact lapping using a single row of larger diameter rebar. To investigate the feasibility and the seismic behavior of the wall, quasi-static experiments were conducted on a total of eight prefabricated shear wall specimens and one cast-in-situ shear wall, and the failure mode, full-range behavior and influence pattern of key parameters were analyzed. The results show t
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