Chondrosarcomas are one of the most common bone tumors in adults. Resectable chondrosarcomas require surgical removal and are prone to local recurrence, often multiple. The article presents a clinical observation of secondary chondrosarcoma of the femur that arose against the background of osteochondroma in a 38-year-old patient. The example shows the role of a multidisciplinary team in choosing the tactics of primary treatment of the patient, as well as in the process of multiple recurrence of the tumor.