Sarkomy Kostej Magkih Tkanej i Opuholi Kozi
The reconstructive stage in the combined treatment of tumors of bones, soft tissues and skin
Currently, a personalized approach is considered a priority in the treatment of malignant neoplasms of bones, skin and soft tissues. The decision on the treatment plan is formed by a multidisciplinary team of specialists: a surgeon, a chemotherapist, a radiotherapist. The active introduction of systemic therapy and new technologies in radiation therapy made it possible to ensure local and systemic control of the disease, which contributed to the expansion of indications for performing organ-preserving surgical interventions. In order to improve functional results, while observing the radica
Read MorePrevalence and prognostic mutation v600e in the braf gene in stage I cutaneous melanoma
Melanoma is one of the most aggressive skin tumors, which occurs against the background of malignant transformation and proliferation of melanocytes. Risk factors for the development of cutaneous melanoma are solar radiation and duration of exposure, old age, individual patient characteristics (light skin, a large number of nevi, including atypical ones, family history) and others. Research in recent years shows that this disease is associated with a number of genetic changes, both congenital and acquired. To study the frequency of occurrence and prognostic significance of the V600E mutatio
Read MoreEffectiveness of titanium mesh in performing oncological endoprosthesis in patients with tumor lesion of the proximal tibia
Oncologic endoprosthesis of the knee joint in patients with tumors of the proximal calf requires reconstruction of the joint and surrounding structures including the extensor mechanism. This study is based on our experience of using titanium meshes as additional fixation aids for attachment of the patellar ligament to the endoprosthesis. We have developed a technique of extensor mechanism reconstruction and performed comprehensive assessment of the results of its clinical use. To evaluate the effectiveness of using titanium meshes for reconstruction of the knee extensor mechanism during pri
Read MoreArtificial intelligence in personalized selection of surgical treatment tactics for bone metastases
Selection of surgical treatment tactics for patients with bone metastases is one of the important problems of modern oncology. In the majority of patients with metastatic bone lesions, surgical interventions are aimed at palliative treatment; however, in some cases of solitary metastases, radical resections with a reconstructive component can be performed. Lifespan prognosis associated with histological structure of malignant tumor is the main and crucial factor in determination of suitable type of surgical treatment. To create software for selection of surgical tactics treatment in patient
Read MoreOmics technologies in diagnosis and treatment of soft tissue sarcomas
Currently, stratification of recurrence risk and prognosis of 5-year survival of patients with soft tissue sarcomas are primarily based on histological tumor classification. Drawing from these data, international oncological societies have proposed a hypothesis about development of gene expression profiling and molecular and genetic diagnosis technologies which will allow to more accurately assess risks of soft tissue sarcoma development and select individual drug treatment.
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