Breast cancer is one of the most significant problems in oncology. This pathology is characterized by increased risk of fractures associated with postmenopausal decrease in bone mineral density, use of hormone therapy, and presence of osteolytic metastases in the spine. All these factors can cause non-traumatic spine fractures decreasing patient mobility and leading to permanent pain syndrome and neurologic deficit. The article presents the modern view on the osteoporosis problem and risk of non-traumatic spine fractures in patients with breast cancer and spine metastases. Literature data on predictors of pathological bone fractures, as well as time and risk of spine metastases in these patients are analyzed. Data of modern studies on the effectiveness of various methods of breast cancer treatment and their combinations, as well as possibilities of minimally invasive surgical interventions, antiresorptive and radiological therapy are considered.